Give the relative rates of reaction of the four carboxylic acid derivatives below with methylamine to give an N-methyl amide. H3C OCH3 H3C CI H3C NH2 H3C CH3 a C d Most reactive 2nd most reactive 3rd most reactive Least reactive Give the relative rates of reaction of the four carboxylic acid derivatives below with aqueous sodium hydroxide to give the sodium carboxylate salt. གཅིག་ལྡན དང་ཅིག་ཡིས་སྡུད་པ་དངའི་ཟག་པ་དཀྱི Most reactive CH3 3 2nd most reactive 3rd most reactive Least reactive H3C NH2 H3C OH

2) Arrange the following carboxylic acid derivatives in the order of reactivity (most strongest tothe right)

Atenolol is a beta blocker medication primarily used to treat high blood pressure and heart- associated chest pain. Other uses include the prevention of migraines and treatment of certain irregular heart beats It is taken by mouth or by injection into a vein. It can also be used with other blood pressure medications. OH .N. CH3 ČH3 H2N° suggest industrial synthetic approach towards synthesis of this drug (atenolol) and provide reasons and advantages of your proposed synthetic approach.

Arrange the following compounds in order of increasing reactivity in nucleophilic acyl substitution. Y OA> B>C OB> C > A OC> A > B O C> B> A OB> A >C OA> C > B B