
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Question
One of the first drugs to be approved for use in treatment of acquired immune deficiency syndrome (AIDS) was azidothymidine (AZT). It is pictured in the image attached.
g) What is the H−O−C bond angle in the side group attached to the five-membered ring (on the far left of the molecule)?
h) What is the hybridization of the oxygen atom in the CH2OH group on the far left of the molecule?

Transcribed Image Text:The image depicts the chemical structure of caffeine, a central nervous system stimulant commonly found in coffee, tea, and other beverages.
### Explanation of the Diagram:
- **Carbon (C):** Represented by the letter "C", most carbon atoms in the structure form the backbone of the molecule.
- **Hydrogen (H):** Represented by the letter "H", hydrogen atoms are bonded to carbon atoms.
- **Oxygen (O):** Represented by the letter "O", oxygen atoms are double-bonded to carbon, shown at the top of the structure.
- **Nitrogen (N):** Represented by the letter "N", nitrogen atoms are part of the rings, contributing to the unique properties of caffeine.
### Structural Features:
- **Methyl Groups (CH₃):** A methyl group is attached to the nitrogen atom in the top ring, contributing to caffeine's hydrophobic properties.
- **Rings:** The two interconnected rings are part of a purine structure, which is a characteristic feature of xanthine derivatives like caffeine.
This molecular structure explains the stimulant effects of caffeine due to its ability to interact with various neuroreceptors in the human brain.
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