Friedel–Crafts alkylation of benzene with (R)-2-chlorobutane and AlCl3 affords sec-butylbenzene.a. How many stereogenic centers are present in the product?b. Would you expect the product to exhibit optical activity? Explain, with reference to the mechanism.

Provide a 3-5 step synthetic route the target molecule from starting material A. Be sure to account for relative stereochemistry and suggest reagents/conditions for each step.

Answer this using betta hydride elimination and alkene stereochemistry.  What are the products for the following reactions? Be aware of alkene stereochemistry.

Answer each question thoroughly nd completely. 1. Thoroughly explain why a halogen, X2 ,cannot be directly added to a benzene ring. 2. What properties does a benzene ring have that allude to its reactivity? 3. What is meant by aliphatic? 4. Explain the different types of oxidations for phenols. Give an example of each with the name of the phenol, and the oxidized phenol product. The examples should be drawn in chemical reaction form. 5. Are phenols reactive? Why or why not? 6. What is meant by an ortho director? Use a reaction as an example. 7. Why is the rate limiting step important in the bromination of benzene? 8. What role does the sigma complex play in electrophilic aromatic substitution reactions? 9. How do Lewis acids play a role in generation of the electrophile? A mechanism will be needed to go along with your explanation. 10. Explain the nitration of benzene reaction. 11. What are deactivating groups, and how do they relate to substitution on the benzene ring? 12. What is the…

25. How many of the following molecules will undergo chlorination at a higher rate than benzene and will produce ortho/para-substituted products? H'os ZON а. One d. Four e. Five b. Two с. Three 1 '1'.

6. Draw all of the stereoisomers that you would form in the reaction of CHCl3 and KOTBU given the following starting materials a-c. b. 7. Draw the product is formed when each alkene is treated with CH212 and Zn(Cu)? a. - 8. Draw the products for the following Grubbs ring-closing metatheses with the following starting materials. 3 а. b. كلمة b. C. be

Rank the compounds in each group according to their reactivity toward electrophilic substitution. 1 = most reactive; 3 = least reactive. a. toluene methoxybenzene fluorobenzene b. p-bromonitrobenzene ✓nitrobenzene ✓phenol

Chem. q4 b i

G.108. With full details  ...