For the following optimisation step, the affinity and potency of compound will be affected mainly by:

Which of the following reaction scheme is expected to atford the tollowing product? HO ОН O The following scheme: 1. Mg, Et,0 Br 2. H H. 3. H;O* O The following scheme: 1. Mg. Et.O HO Br H. H30* O The following scheme: 1. TBS-CI, imid., CH CI, HO Br 2 Mg. Et,0 3. H. 4 H30* 5 Bu N*F THF O The following scheme: 1. Mg. Et,O Br 2. 3. H3O* O The following scheme: 1 BrMg 2 H;0 astime

text Nu Whe ofect wokl hgh presure have on the proketon of NOg? Why? 4 Wharwoud be the efat of ach of the fulowing on the equilbrium iimvolving the reacion o coke (C (s) when e prokre CO and H C) H,0) cog)+ H,(E) Akten of steam An increase in pvessure Removal of H as it is prodced Akng a catalst S he birding of axygen to hemagbbin (abbreviated Hb). giving oxyhemogldbin (HbO,) s partially glaed by he compk ad tcan be summarized as bolows: contraon of H and CO, in the blood. Although the equilibrum is very HbO, H CO, co,HbH + o, Accordg to Le Chaelers Princpe what wauld be the effect of each of the following on the squban? a The produc on of ac acid (whch contairs Hr) and CO, in a muscle during vigorous exercise? ng besh oxygen aiched a?

Nernst equation for pair IO3 |I': RT E = E° + nF In a(10;)a°(H*) a(I¯) RT a(IO;)a(H") E = E° + nF a(I") RT E = E° –- nF In a(IO; )a°(H*) a(I¯) nF a(IO,)a°(H*) lg RT E = E° + a(I¯)