Propose mechanisms for the conversion of A to B and of B to C. What is the function of sodium amide in each reaction? Following is a synthesis for the antiarrhythmic drug bidisomide. The symbol Bn is anabbreviation for the benzyl group, C,H,CH,–1. NANH,1. NANH,H,SO,BnCN2.CNCNCIBnABC NH2NH2NH2N-BnN-HEBidisomide

Answered: Following is a synthesis for the…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter23: Carbonyl Condensation Reactions

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Propose mechanisms for the conversion of A to B and of B to C. What is the function of sodium amide in each reaction?

Following is a synthesis for the antiarrhythmic drug bidisomide. The symbol Bn is an
abbreviation for the benzyl group, C,H,CH,–
1. NANH,
1. NANH,
H,SO,
Bn
CN
2.
CN
CN
CI
Bn
A
B
C

Expert Solution

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Bidisomide, is an antiarrhythmic drug and was selected for development from a series of chemically related structures on the basis of its antiarrhythmic activity in experimental models, its favorable side effects profile,( mainly the relative absence of negative ionotropism andanticholinergic activity and its wide safety margin). The molecular weight of bidisomide is 407.98. the empirical formula is C₂₂H₁₁ClNO₂.

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