Flg. 1. Breast cancer families 1 to 7. Solid circles, females with breast cancer; open circles, fe- males without breast cancer; open squares, males without breast cancer. The age given for each woman is age at (first) breast can- cer diagnosis (dx) if affected, age at death if deceased (deceased in- dividuals are represented by diag- onal lines through symbols), or age at most recent interview if alive without breast cancer. Al-
How to calculate the recombination rate between the marker and the gene?
For example, how to calculate the recombination rate between the D17S74 marker and the breast cancer gene?
Solution:-
We are given the following probabilities:
P(woman will develop breast cancer gene) = 1/10
P(woman has mutation of D17S74 marker) = 1/550
P(woman will develop breast cancer gene| woman has mutation of D17S74 marker) =8/10
Now, we are asked to calculate the probability that a randomly selected woman will develop breast cancer gene given that she has a
mutation of the gene is given by:P(woman will develop breast cancer gene | woman has mutation of DS17S74) = 8/10 = 0.8
Now, we are asked to calculate the probability of a randomly selected woman carrying a mutation of the DS17S74 gene and that she will develop breast cancer too. This probability is given by.
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