Fill in the information based on the type of reaction mentioned in each column.  A. Draw the line angle diagram of a substrate that will undergo SN1, SN2, E1, E2 B. Draw the line angle diagram of a nucleophile that can be used for SN1, SN2, E1, and E2 C. Draw the line angle diagram of a solvent that can be used with SN1, SN2, E1, and E2 D. Write down if the stereochemistry of the product will be inversion, retention, or a 50:50 ratio of inversion and retention

5. (Rank the substrates in order of increasing reactivity in an SN2 reaction. (1 = least reactive, 4 = most reactive) Br of Br Br Br

Question 3 of 4 O Macmillan Learning Determine whether each of these reactions occur through an SN 1, SÃ2, E1, or E2 mechanism. A. > B. Br Br (CH3)3CONa (CH3)3COH CH3ONa THE O + Na Br + CH3 Na Br A. The mechanism of Reaction A is: SN2 E2 SN 1 E1 B. The mechanism of Reaction B is: E1 E2 SN2 SN 1

1. Draw 2-methylpropanoic acid + thionyl chloride/pyridine catalysis + heat = ibuprofen intermediate  C4H6OCI is the answer for the first intermediate  (this one I already have it) 2. Draw ibuprofen intermediate 1 + benzene + AlCl3 + heat = ibuprofen intermediate 2. 3. Draw ibuprofen intermediate 2 + hydrazine = ibuprofen intermediate 3. 4. Draw ibuprofen intermediate 3 + KOH + heat = ibuprofen intermediate 4. 5. Draw ibuprofen intermediate 4 + ethanoyl chloride + AlCl3 + heat = ibuprofen intermediate 5. 6. Draw ibuprofen intermediate 5 + NaBH4 + hydronium workup = ibuprofen intermediate 6. (this one I have it already) 7. Draw ibuprofen intermediate 6 + HBr = ibuprofen intermediate 7.   (this one i have it already)8. Draw ibuprofen intermediate 7 + Mg = ibuprofen intermediate 8. 9. Draw ibuprofen intermediate 8 + CO2 = ibuprofen intermediate 9. 10. this is the ibuprofen (i already have it)

It will be helpful if I find the distinction between these two products since they are both Elimination reactions?   Will one proceed via E1 or E2? If so, why is that the case?

4) When a mixture of two different compounds both containing a hydrogens are placed under acidic or basic conditions, crossed aldol products can be formed. By either self-condensation or cross condensations. Draw the 4 aldol and 4 a.B-unsaturated ketones that can be made from the following mixed system. -OH 4 products One way to control this is by either having only one compound with a hydrogens or by reacting the desired nucleophile with lithium diisopropylamide (LDA) before addition of second carbonyl. The issue here is that this reaction stops at the aldol unless excess base is used. он LDA OH heat Show a synthetic scheme of how to use the following carbonyls to control the formation of each cross product (i.e. each as nucleophile and electrophile, two reactions). and

11. Determine whether each reaction occurs by an SN2, SN1, E1, and/or E2 reaction. Provide a detailed mechanism with curved arrows and the major product(s). OMs Br Br OH мон OH NaSH DMF NaOH H₂O, heat LDA DMF NaOH H₂O, heat HBr H, H₂O heat

6. Provide the product for each of the following reaction. Indicate the type of reaction based on the reaction conditions. Show the complete mechanism for each reaction. Show the energy diagram for the reaction. F3C. CH3 CH3OH 25 °C

For each problem  a. Identify the nucleophile and the electrophile in each step.b. Depending on which is missing, either draw in the appropriate arrows toillustrate how the product is formed, or draw in the product of the reaction. c. If both are missing (aka 1e), both draw in the product and draw the appropriate arrows.

7. Each of the following synthesis will not produce the desired product. Explain the flaw in each synthesis. NO2 1. HNO3, H2SO4. 2. ETCI, AICI, a. 1. Br2, FeBr3 2. AICI3, Br b.