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- explain in detail why paracetomal gives no risk of hepatric toxicity.What is the advantage of MALDITOF MS?"An obese man was prescibed the lipophilic drug phenobarbital for treatment of seizures. He noticed that it took time before his seisures stopped. What pharmacokinetic parameter increased? How did this affect the time till steady state? B) The patient is noncompliant. A) Clearance; shorter time till steady state ☐ ▪ B) half-life; longer time till steady state. C) half-life; shorter time till steady state. ▪ True or False: hepatic enzyme activity is dependent on age. Therefore, concentration of drugs with High EH are affected A)T B)F Match the drug type with the condition that affects clearance of the drug: A) Low EH drug B) High EH drug 1) Heart failure 2) Liver disease