Answered: Explain Biological Friedel–Crafts…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Explain Biological Friedel–Crafts Reactions ?

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Step 1

Charles Friedel and James Crafts developed Friedel-Crafts reactions in 1877. Friedel-Craft alkylation and acylation are the major types of these reactions. The substituent in the Friedel-Craft reaction is attached to the aromatic rings.

Features of Friedel-Craft reactions:

In the Friedel-Craft reaction, the process of generating an electrophile occurs, and it will work as a lewis acid as well as coordinate with the halogens.
The replacement reaction in which aromatic proton is replaced with the alkyl group is known as Friedel-Craft Alkylation.
In the Friedel-Craft alkylation reaction, electrophile will attack the aromatic ring through carbonation.
The reaction consists of acyl group addition on the aromatic ring is known as Friedel-craft Acylation.
The aromatic ring will be converted into ketone in the Friedel-Craft acylation process.

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