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Briefly explain this statement "Preformulation studies help to find the drug performance and the development of a dosage form"-explain this with different drug properties and example? Please answer at your own easy words.
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- Please briefly explain How preformulation studies help to find the drug performance and the development of a dosage form-Briefly explain this with different drug properties and example? Please briefly answer at your own easy words.Briefly elaborate How preformulation studies help to find the drug performance and the development of a dosage form-Briefly explain this with different drug properties and example? Please answer at your own easy words.What is more preferred for drug therapy, conventional or modified release dosage forms? Please provide informations that would support the claim.
- As a pharmacist, propose some improvement that can be implemented to further improve the formulation stability. Answer the following case study using your own words.Answer the following questions:1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product?2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product?3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)?4. How could the manufacturing process affect drug product performance?5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived?6. What is meant by “sink” conditions?7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration?8. For a lipid-soluble drug that has very poor aqueous solubility, what…What is the mechanism of action of the drug LIDOCAINE? pls. dont plagiarize
- What properties of drug are relevant for developing modified release drug delivery formulation. Please briefly explain this at your own words.Make a drug study study about cetirizine (diphenhydramine hydrochloride) drug and fill up the corresponding details in the table. MAIN DRUG: cetirizine (diphenhydramine hydrochloride) INFORMATION: Cetirizine Age: 18/F Occupation: Basketball player Weight and BMI: 50 KGS/22 Blood pressure: 100/70 Heart rate: 60 Respiratory rate: 15 Temperature: 36.2 Diagnosis: Allergic reaction with eating shrimp with facial angioedema Chief complaint: Swollen ears and mouth Prescription: Cetirizine PO 5 mg OD