ermediates. Identify the name of the reaction in each step. 20 mol% Pd(PPH3)4

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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The total synthesis of macrocyclic compound D is illustrated below. Draw the structure of D and its synthetic
intermediates. Identify the name of the reaction in each step.
...
20 mol% Pd(PPH3)4
-B
A
MECN, rt
CHO
ОНС
Bz
LDA
NaOH
A
B
but-3-enal
THF, -78 °C, 12h
Сно
Grubbs catalyst II (10 mol%)
DCM, reflux, 48h
Transcribed Image Text:The total synthesis of macrocyclic compound D is illustrated below. Draw the structure of D and its synthetic intermediates. Identify the name of the reaction in each step. ... 20 mol% Pd(PPH3)4 -B A MECN, rt CHO ОНС Bz LDA NaOH A B but-3-enal THF, -78 °C, 12h Сно Grubbs catalyst II (10 mol%) DCM, reflux, 48h
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