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- QUESTION 4 The following two individuals are crossed: Aa Bb Cc Dd x Aa bb Cc Dd What proportion of the progeny will have the following genotype? Express as either a fraction or as a decimal; Please round to 3 decimal places] Aa Bb CC dd p= What is the probability that one of the progeny will have all dominant OR all recessive phenotype?p=Question 9 Consider that a certain gene is a maternal effect gene and that the allele for dark brown pigment is incompletely dominant to the allele for no pigment (white). The incomplete dominant phenotype is light tan. If a heterozygous female is crossed with heterozygous male, what will be the phenotypic ratio of the progeny? A) 1 dark brown: 2 light brown: 1 white. B) 3 dark brown: 1 white C). all dark brown D) all light tan E) cannot be determined CS Scanned with CamScannerzzle My Classes Copy ink Peoigree MULTIPLE CHOICE QUESTION 1 What clue is found in this pedigree to let you know that this trait is an autosomal dominant trait? 1 4 6. The trait skips a generation. II Affected parents have affected offspring. 1 2 3 4 5 The trait is only found in females and it skips a generation. Autosomal dominant tráit The trait is only in males. !
- QUESTION 4 What is the mode of inheritance for the following pedigree? OX-linked recessive O Y-linked O X-linked dominant O Autosomal recessive O Autosomal dominant 11 IV DOOD 1 2 3 4 OI 2 1 2 3 3 5 сто 1 2 4 5 6 6 7 8 9 4 5 6 7 7 8 DO 10 11 12 8 9QUESTION 8 Consider the following pedigree. With no other information provided, what is the most likely mode of transmission (or mode of inheritance) of the allele for the unusual trait? sex-linked recessive autosomal recessive autosomal dominant sex-linked dominantQuestion 1 What are the haploid genotypes of the gametes and frequencies/proportions of those gametes that can be formed in individuals of each of the following diploid genotypes? (DON’T do a cross. Just predict the different haploid gamete genotypes that could be produced by each diploid genotype below.) Proportions can be expressed in ratio form or fractional form. Dd Ee ff GG Mm Nn Rr ZZ
- QUESTION 3 Linkage disequilibrium is defined by which of the following? O Positions in the genome where people vary by a single nucleotide base O The occurrence of two alleles in the repulsion configuration O The probability that two genes are linked O Crossing over that occurs between two genes that are located close to each other O The nonrandom association between alleles in a haplotype QUESTION 4 Red-green color blindness is a human recessive X-linked disorder. A young man with a 47, XXY karyotype (Klinefelter syndrome) is colorblind. His mother and father have normal color vision, but his mother has a father who is colorblind Did the nondisjunction event that gave rise to the young man with Klinefelter syndrome happen in the mother, the father or is it impossible to tell (assume that no crossing over took place in prophase I of meiosis)? a. Mother b. Father c. Impossible to tell Did this nondisjunction happen during Meiosis I, Meiosis II, or is it impossible to tell? a. Meiosis I…A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What if the couple wanted prenatal testing so that a normal fetus could be aborted?A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What is the chance that this couple will have a child with two copies of the dominant mutant gene? What is the chance that the child will have normal height?
- A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. Should the parents be concerned about the heterozygous condition as well as the homozygous mutant condition?QUESTION 10 Consider the following pedigree. With no other information provided, what is the most likely mode of transmission (or mode of inheritance) of the allele for the unusual trait? autosomal dominant sex-linked recessive autosomal recessive O sex-linked dominantQuestion 6 Which of the Pedigree Diagrams below is most likely to show a family with Becker muscular dystrophy? B Afected female Normal fenale anecad sale Nermal maie KEY Homozygous Homazygous Heterozygous Heberozygous Wild Type Male Fumale Male Female Male Female Note: Completely red symbol denotes an individual exhibiting the phenotype of interest C OT 12 12 12 IV 1/4 14 Alfected 12. 1/2 Known camer A A B. A, 8.