Eosinophilic (31 %) 10 (11 %) Neutrophilic (29 %) Highly Atopic :(25 %) (4 %) FIG 1. Asthma sputum proteomes/proteotypes/subphenotypes. The network was created by using TDA of protein data sets from all asth (mild/moderate and severe) participants and consisted of 10 cluster we termed proteotypes. Differently colored nodes and edges d different clusters. Dotted boundaries represent clusters grouped acco to shared granulocyte and atony profiles whereas proteome clusters

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Chapter17: Genes And The Immune System
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please explain the figure

Eosinophilic (31 %)
10
(11 %)
Neutrophilic
(29 %)
Highly Atopic
:(25 %)
(4 %)
FIG 1. Asthma sputum proteomes/proteotypes/subphenotypes. The data
network was created by using TDA of protein data sets from all asthmatic
(mild/moderate and severe) participants and consisted of 10 clusters that
we termed proteotypes. Differently colored nodes and edges denote
different clusters. Dotted boundaries represent clusters grouped according
to shared granulocyte and atopy profiles, whereas proteome clusters delin-
eated by continuous boundaries represent subphenotypes. Connections
(lines) between nodes represent overlap of patients between nodes/clus-
ters. The percentage of participants in each phenotype is displayed adja-
cent to the phenotype name.
Transcribed Image Text:Eosinophilic (31 %) 10 (11 %) Neutrophilic (29 %) Highly Atopic :(25 %) (4 %) FIG 1. Asthma sputum proteomes/proteotypes/subphenotypes. The data network was created by using TDA of protein data sets from all asthmatic (mild/moderate and severe) participants and consisted of 10 clusters that we termed proteotypes. Differently colored nodes and edges denote different clusters. Dotted boundaries represent clusters grouped according to shared granulocyte and atopy profiles, whereas proteome clusters delin- eated by continuous boundaries represent subphenotypes. Connections (lines) between nodes represent overlap of patients between nodes/clus- ters. The percentage of participants in each phenotype is displayed adja- cent to the phenotype name.
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