Elevated alanine aminotransferase (ALT), a liver enzyme, is an indicator of severe illness among individuals infected with COVID-19. Suppose we wanted to conduct a study to compare the mean ALT concentration (U/L) between a sample of adult patients hospitalized at MUSC for COVID-19 infection (x=23.0, s=5.2) to the mean ALT concentration (U/L) of healthy U.S. adults (u=20.0, σ=12.3). How many patients would we need to enroll from MUSC to conduct this study with 95% confidence, and 80% power? From: Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study [published correction appears in BMJ. 2020 Mar 31;368:m1295]. BMJ. 2020;368:m1091. Published 2020 Mar 26. doi:10.1136/bmj.m1091 193 132 243 270

Glencoe Algebra 1, Student Edition, 9780079039897, 0079039898, 2018
18th Edition
ISBN:9780079039897
Author:Carter
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Chapter10: Statistics
Section10.6: Summarizing Categorical Data
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Elevated alanine aminotransferase (ALT), a liver enzyme, is an indicator of severe
illness among individuals infected with COVID-19. Suppose we wanted to conduct
a study to compare the mean ALT concentration (U/L) between a sample of adult
patients hospitalized at MUSC for COVID-19 infection (x=23.0, s=5.2) to the mean
ALT concentration (U/L) of healthy U.S. adults (u=20.0, σ=12.3). How many
patients would we need to enroll from MUSC to conduct this study with 95%
confidence, and 80% power?
From: Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019:
retrospective study [published correction appears in BMJ. 2020 Mar 31;368:m1295]. BMJ. 2020;368:m1091.
Published 2020 Mar 26. doi:10.1136/bmj.m1091
193
132
243
270
Transcribed Image Text:Elevated alanine aminotransferase (ALT), a liver enzyme, is an indicator of severe illness among individuals infected with COVID-19. Suppose we wanted to conduct a study to compare the mean ALT concentration (U/L) between a sample of adult patients hospitalized at MUSC for COVID-19 infection (x=23.0, s=5.2) to the mean ALT concentration (U/L) of healthy U.S. adults (u=20.0, σ=12.3). How many patients would we need to enroll from MUSC to conduct this study with 95% confidence, and 80% power? From: Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study [published correction appears in BMJ. 2020 Mar 31;368:m1295]. BMJ. 2020;368:m1091. Published 2020 Mar 26. doi:10.1136/bmj.m1091 193 132 243 270
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