EBV Epithelium EBV attaches to and infects epithelium of the throat, where it replicates and causes pharyngitis. -Lymphatic vessel - Blood vessel Virions enter the lymphatic vessels and are carried to the lymph nodes. Some virions escape the lymph nodes and are carried to the bloodstream. -Lymphatic vessel Lymph node Virions attach specifically to B lymphocytes and infect them, producing either latent or productive infections. Viral genome -Latently infected B cell Productively infected B cell Productively infected B cell Activated lymphocyte Plasma cells Viral %24 genome Lysed B cell Effector cytotoxic T cell Heterophile antibodies T cells respond to infection and destroy the lymphocytes that have replicating EBV. Latently infected B cells are not attacked by T cells. They differen- tiate into plasma cells and produce random immunoglobulins, including heterophile antibody. FIGURE 25.7 Pathogenesis of Infectious Mononucleosis

A wound is damaged or breaks in the surface of the skin. The wound is divided into two types, they are acute wound that includes minor cuts, laceration, bites, etc, and chronic wounds that can become slow to heal including ulcers on the legs and feet. R…