During electrophilic aromatic substitution, a resonance-stabilized cation intermediate is formed, Groups, already present on the benzene ring, that direct ortho/para further stabilize this intermediate by participating in the resonance delocalization of the positive charge. resonance Assume that the following group is present on a benzene ring at position 1 and that you are brominating the ring at positon 4. In the box below draw the structure of the rese contributor that shows this group actively participating in the charge delocalization. H₂C • You do not have to consider stereochemistry. • You do not have to explicitly draw H atoms. . Do not include lone pairs in your answer. They will not be considered in the grading.

order the following carbonyl groups in terms of reactivity with nucleophiles (least reactive first) acetaldehyde formaldehyde  acetone acetyl chloride  acetic acid

Draw the MAJOR organic product(s) for each of the following reactions/sequence of reactions. OEt ΕΙΟ OEt OH 1) PCl3 / Br₂ NH2 2) / pyridine 1) EtONa / EtOH 2) H3O+ (dilute) 1) EtONa / EtOH 2) Ph 3) NaOH / H₂O Br 4) H2SO4/H₂O/heat OH 1) SOCI₂ 2) HO- / Et₂N NO2 1) MCPBA / CF3SO₂H 2) Ph-NH2/pyridine 1

synthesis for this

In the presence of a base which of the following will not form an enolate?

Pls help ASAP on both pls I HUMBLY request

please explain the mechanism of ring opening of an epoxide by reaction with nucleophile under acidic conditions

H2SO4 CH3CH2OH CH3CH2OCH2CH2OH Ethylene oxide is the starting material for the synthesis of Cellosolve, an important industrial solvent. Write a detailed mechanism for this synthesis (shown above). Then draw curved arrows that depict electron reorganization for Step 1 (assume this is a proton transfer step) of the mechanism shown below. Unless specified otherwise, do not count proton transfers when counting steps. The starting materials of this step are provided. Arrow-pushing Instructions H H2C CH2 H3CH2C H

Draw the three intermediates, including resonance structures, for the attack of nitronium ion on pyridine. Which position(s) is favored? Why?

Draw the structure of each of the organic precursors in the following two-step synthesis.