Organic Chemistry
8th Edition
ISBN: 9781305580350
Author: William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher: Cengage Learning
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The Robinson annulation is a combination of two carbonyl coupling reactions, the Michael reaction and the intramolecular aldol condensation The most
common partners in the reaction are a nucleophilic donor (such as a cyclic ketone, a B-keto ester, an enamine, or a B-diketone) and an aB-unsaturated ketone
acceptor. The product is a substituted 2-cyclohexenone derivative.
Draw the structures of the nucleophilic 6-ketro ester and theaB-unsaturated ketone acceptor that were conbined in a Robinson annulation to give the following
product
Ph
CO,Et
• Draw the B-keto ester as an ethyl ester,
P.
Activate(Previous Ows
GoithSertinc
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- The Robinson annulation is a combination of two carbonyl coupling reactions, the Michael reaction and the intramolecular aldol condensation. The most common partners in the reaction are a nucleophilic donor (such as a cyclic ketone, a β-keto ester, an enamine, or a β-diketone) and an α,β-unsaturated ketone acceptor. The product is a substituted 2-cyclohexenone derivative. Draw the structures of the nucleophilic β-diketone and the α,β-unsaturated ketone acceptor that were combined in a Robinson annulation to give the following product:arrow_forwardThe overall reaction produced by the aldol condensation of acetophenone and benzaldehyde is shown below. + NaOH, A Acetophenone Benzaldehyde Chalcone Which of the following steps are involved in the mechanism that leads to the formation of chalcone? он + он H OH он + Он OH + Тон Он он + + Он ОН + онarrow_forwardWhich of the following is a key intermediate for the reaction in the box? A) Benzophenone B) Benzoic acid C) Benzaldehyde D) Phenyl methyl etherarrow_forward
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