Double-strand break 13' Homologous chromatids Strand degradation occurs at the double-strand break site to yleld single-stranded ends. Strand Invaslon causes D-loop formation. D-loop Gap repalr synthesis fills in the vacant reglons. щии பாபபா Branch migration and resolution can produce recombinant or nonrecombinant chromosomes. Nonrecombinant chromosomes Recombinant chromosomes Crossover site FIGURE 20.3 A simplified version of the double-strand break model. For simplicity, this illustration does not include the formation of heteroduplexes. The dashed arrow indicates that the pathum ta tha la mm be lacr fawond

Describe alternating splicing and its biological significance with a specific example.

What are histone octamer?

Name the three non-sense codons?

Consider the mechanism of the enzyme RNase:   What would happen to the Km (i.e., would it increase, decrease, or stay the same) if the his12 was mutated to a lysine? Explain.   What would happen to the Kcat (i.e., would it increase, decrease, or stay the same) if the his12 was mutated to a valine? Explain.

What are aminoacyl-tRNA synthetases?

What is an SMC complex? Describe two examples

Explain what is meant by the coupling of transcription and translation in bacteria. Does coupling occur in bacterial and/or eukaryotic cells? Explain.