Deuterium (D) is an isotope of H. Both D and H have one proton and one electron; H has no neutrons and D has one. Consequently, D and H have nearly identical behavior, but they can be distinguished from each other experimentally due to their different masses. Therefore, replacing an H with a D in a molecule-deuterium isotope labeling-can provide valuable information about a mechanism. With this in mind, how would you synthesize each of the following deuterium-labeled compounds from the analogous unlabeled compound, using D,0 as your only source of deuterium? Hint: You will have to use two separate proton transfer reactions to synthesize each one. (a) (b) (c) OD D.

Mechanism Explorer: Sketch and Submission Reaction Explorer Help (Intermediate) Reactant (Intermediate) Product (X) CH3 HÖ-S=0: Apply Mechanism H,C Hint Solution 8 remaining step(s) can be solved Tip: Only add curved arrows in this sketcher

Compound A reacts with B in the presence of sodium hydride to give C as the majority product.1. Give the detailed mechanism of the formation of C and draw the product C in the box above.2. Draw the energy diagram of the reaction. Indicate with an arrow the rate-determining step of the reaction then draw its transition state3.The rate of the reaction observed is 5 x 10-2 M.s-1 when the concentrations of A and B are 0.2 M and 0.1 M respectively.Determine the rate of the reaction if the concentrations of A and B are now 0.3 M and 0.2 M respectively. Show your calculation

There are two mechanisms by which each of the C1 atoms in the following molecule can be replaced by another group: ⚫ Mechanism 1: The C1 atom can be replaced with a concerted, bimolecular step. Mechanism 2: The C1 atom can be replaced in several steps, the slowest of which is unimolecular. Highlight in red the C1 atom that would be replaced the fastest if the reaction went Mechanism 1. Highlight in blue the C1 atom that would be replaced the fastest if the reaction went Mechanism 2. If you would choose the same C1 to be replaced fastest by both mechanisms, highlight it in green instead. C1 cl. C1