Describe the study sample. Complete the following table to describe the study sample using data collected at the first examination for each participant (n = 4434). Summarize your results in three to four sentences. Patient Characteristic* Total Sample (n = 4434) Age, years 49.93 (8.68) Male sex 1944 (43.84) Systolic blood pressure, mmHg 132.91 (22.42) Hypertension 3252 (73.34) Use of anti-hypertensive medication 144 (3.25) Current smoker 2181 (49.19) Total serum cholesterol, mg/dL 236.98 (44.65) Serum Glucose 82.19 (24.40) Stroke 415 (9.36) * Mean (Standard deviation) or n (%)

Definition Definition Measure of central tendency that is the average of a given data set. The mean value is evaluated as the quotient of the sum of all observations by the sample size. The mean, in contrast to a median, is affected by extreme values. Very large or very small values can distract the mean from the center of the data. Arithmetic mean: The most common type of mean is the arithmetic mean. It is evaluated using the formula: μ = 1 N ∑ i = 1 N x i Other types of means are the geometric mean, logarithmic mean, and harmonic mean. Geometric mean: The nth root of the product of n observations from a data set is defined as the geometric mean of the set: G = x 1 x 2 ... x n n Logarithmic mean: The difference of the natural logarithms of the two numbers, divided by the difference between the numbers is the logarithmic mean of the two numbers. The logarithmic mean is used particularly in heat transfer and mass transfer. ln x 2 − ln x 1 x 2 − x 1 Harmonic mean: The inverse of the arithmetic mean of the inverses of all the numbers in a data set is the harmonic mean of the data. 1 1 x 1 + 1 x 2 + ...