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Describe the changes that occur in each step of the mechanism.

Describe the changes that occur in each step of the mechanism.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Describe the changes that occur in each step of the mechanism.

H- H-N. No (e) Acyl-enzyme HO-C=O CH H CH-CH₂ (1) Enzyme-product complex Asp 102 0=0, H (b) First tetrahedral intermediate Aap 100 % His 5/ CH-CH₂ Ni+H- His 57 (e) Second tetrahedral intermediate CH (a) Enzyme-substrate complex CH Ser 196 CH₂ Gly 193 =0 Ser 196 Gly 193 (d) Acyl-enzyme FIGURE 6.19 The Probable Mechanism of Action of Chymotrypsin. The mechanism involves a fast acylation step when the carbonyl and of the target peptide boad of the substrate is transferred to the enzyme to form an acyl-enzyme adduct and the amino end of the substrate leaves the active site. A second slow deacylation of the enzyme follows, releasing the carbonyl end of the substrate
Transcribed Image Text:H- H-N. No (e) Acyl-enzyme HO-C=O CH H CH-CH₂ (1) Enzyme-product complex Asp 102 0=0, H (b) First tetrahedral intermediate Aap 100 % His 5/ CH-CH₂ Ni+H- His 57 (e) Second tetrahedral intermediate CH (a) Enzyme-substrate complex CH Ser 196 CH₂ Gly 193 =0 Ser 196 Gly 193 (d) Acyl-enzyme FIGURE 6.19 The Probable Mechanism of Action of Chymotrypsin. The mechanism involves a fast acylation step when the carbonyl and of the target peptide boad of the substrate is transferred to the enzyme to form an acyl-enzyme adduct and the amino end of the substrate leaves the active site. A second slow deacylation of the enzyme follows, releasing the carbonyl end of the substrate
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