Cystic fibrosis (CF) is an autosomal recessive disorder. Several different individual point mutations in the CFTR gene cause cystic fibrosis. Two of the most common mutations (A and B) are shown on the diagram below. The lines below the gene represent ASO (allele-specific oligonucleotide) probes and the regions of the gene to which they hybridize. The "wild type" probe hybridizes to the wild type allele and the "mutant" probe hybridizes to the mutant allele of this gene. А B CFTR gene Probe 1 wild type Probe 3 wild type Probe 2 mutant Probe 4 mutant Five people underwent ASO testing for cystic fibrosis using all four of the probes shown below. The results of this test are shown in the diagram. #1 #2 #3 #4 #5 Probe 1 Probe 2 Probe 3

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