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Cystic fibrosis (CF) is an autosomal recessive disorder. Several different individual point mutations in the CFTR gene cause cystic fibrosis. Two of the most common mutations (A and B) are shown on the diagram below. The lines below the gene represent ASO (allele-specific oligonucleotide) probes and the regions of the gene to which they hybridize. The "wild type" probe hybridizes to the wild type allele and the "mutant" probe hybridizes to the mutant allele of this gene. А B CFTR gene Probe 1 wild type Probe 3 wild type Probe 2 mutant Probe 4 mutant Five people underwent ASO testing for cystic fibrosis using all four of the probes shown below. The results of this test are shown in the diagram. #1 #2 #3 #4 #5 Probe 1 Probe 2 Probe 3

Cystic fibrosis (CF) is an autosomal recessive disorder. Several different individual point mutations in the CFTR gene cause cystic fibrosis. Two of the most common mutations (A and B) are shown on the diagram below. The lines below the gene represent ASO (allele-specific oligonucleotide) probes and the regions of the gene to which they hybridize. The "wild type" probe hybridizes to the wild type allele and the "mutant" probe hybridizes to the mutant allele of this gene. А B CFTR gene Probe 1 wild type Probe 3 wild type Probe 2 mutant Probe 4 mutant Five people underwent ASO testing for cystic fibrosis using all four of the probes shown below. The results of this test are shown in the diagram. #1 #2 #3 #4 #5 Probe 1 Probe 2 Probe 3

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Cystic fibrosis (CF) is an autosomal recessive disorder. Several different individual point mutations in the CFTR gene cause cystic fibrosis. Two of the most common mutations (A and B) are shown on the diagram below. The lines below the gene represent ASO (allele-specific oligonucleotide) probes and the regions of the gene to which they hybridize. The "wild type" probe hybridizes to the wild type allele and the "mutant" probe hybridizes to the mutant allele of this gene. В CFTR gene Probe 1 wild type Probe 3 wild type Probe 2 mutant Probe 4 mutant Five people underwent ASO testing for cystic fibrosis using all four of the probes shown below. The results of this test are shown in the diagram. #1 #2 #3 # 4 #5 Probe 1 Probe 2 Probe 3 Probe 4
Transcribed Image Text:Cystic fibrosis (CF) is an autosomal recessive disorder. Several different individual point mutations in the CFTR gene cause cystic fibrosis. Two of the most common mutations (A and B) are shown on the diagram below. The lines below the gene represent ASO (allele-specific oligonucleotide) probes and the regions of the gene to which they hybridize. The "wild type" probe hybridizes to the wild type allele and the "mutant" probe hybridizes to the mutant allele of this gene. В CFTR gene Probe 1 wild type Probe 3 wild type Probe 2 mutant Probe 4 mutant Five people underwent ASO testing for cystic fibrosis using all four of the probes shown below. The results of this test are shown in the diagram. #1 #2 #3 # 4 #5 Probe 1 Probe 2 Probe 3 Probe 4
Which individual(s) have only wild type alleles (homozygous dominant)? # 4 #1 #2 #5 #3
Transcribed Image Text:Which individual(s) have only wild type alleles (homozygous dominant)? # 4 #1 #2 #5 #3
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