Create your own SN1 reaction and label the steps 1) heterolysis of leaving group 2) coordination of nucleophile 3) Proton transfer

2. Draw the structures and explain why CH3CH₂O and CH3CO₂ are good nucleophiles but CH3SO3, water, and alcohols (R-OH) are poor nucleophiles. Propose a 'cutoff' for the amount of negative charge needed to be a good nucleophile. CH3CH₂O CH3CO₂ CH3SO3 H₂O CH₂OH

Draw a detailed arrow pushing mechanism for the following reaction. In the rate-determining step unimolecular (SN1) or bimolecular (SN2)

rank these from least to most reactive in nucleophilic acyl substitution with a nucleophile   I)CH3COOC2H5 II) CH3COO-Na+ III)CH3COCl IV) CH3CONH2

A student proposes the following reaction mechanism for the reaction in Model 6. Which step inthis mechanism is least favorable? Explain your reasoning.

Which of the following is a substitution reaction? “人一X II. スーズ I. 00 OH "メー人 IV. III. Br 人ー人 SH 1) 1 2) 11 3) l1 4) IV

e 2. Draw the structures and explain why CH3CH₂O and CH3CO₂ are good nucleophiles but CH3SO3, water, and alcohols (R-OH) are poor nucleophiles. Propose a 'cutoff for the amount of negative charge needed to be a good nucleophile. CH3CH₂O CH3CO₂ CH3SO3 H₂O CH3OH

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Answer the question below the reaction. ta The reaction above proceeds through which type of mechanism? SN2 SN1 E1 E2 OH + Excess NH4C1 H₂SO4 + H₂O

This reaction is an example of conjugate addition of a nucleophile to an a,ẞ-unsaturated carbonyl. O CH3CH2CH2CH=CHCSCOA H₂O OH CH3CH2CH2CHCH2CSCOA Draw the two resonance structures of the enolate anion intermediate for this reaction. • Draw an R1 group in place of COA. The R group tool is located in the charges and lone pairs drop-down menu. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. • Separate resonance structures using the symbol from the drop-down menu. ->> 90-87 O + ? ChemDoodle >