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Consider the hypothetical serine protease, which shows the specificity pockets. The S₁ pocket has a glutamic acid in the bottom, the S₂ pocket is small and hydrophobic, and the S₁' pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. Which of the sequences would this protease cleave? R3 IZ 18² S₂ ZI 5 R I R₁ S₁'

Consider the hypothetical serine protease, which shows the specificity pockets. The S₁ pocket has a glutamic acid in the bottom, the S₂ pocket is small and hydrophobic, and the S₁' pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. Which of the sequences would this protease cleave? R3 IZ 18² S₂ ZI 5 R I R₁ S₁'

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Q21:

Consider the hypothetical serine protease, which shows the specificity pockets. The S₁ pocket has a glutamic acid in the bottom, the S₂ pocket is small and hydrophobic, and the S₁' pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. Which of the sequences would this protease cleave? Val-Phe-Arg Arg-Phe-Val Phe-Arg-Val Val-Arg-Phe Arg-Val-Phe Phe-Val-Arg Incorrect ZI R3 Il H ZI H S2 ZT S₁ Y "Ri S₁
Transcribed Image Text:Consider the hypothetical serine protease, which shows the specificity pockets. The S₁ pocket has a glutamic acid in the bottom, the S₂ pocket is small and hydrophobic, and the S₁' pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. Which of the sequences would this protease cleave? Val-Phe-Arg Arg-Phe-Val Phe-Arg-Val Val-Arg-Phe Arg-Val-Phe Phe-Val-Arg Incorrect ZI R3 Il H ZI H S2 ZT S₁ Y "Ri S₁
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