Compartmentation in ß oxidation. Free palmitate is activated to its coenzyme A derivative (palmitoyl-CoA) in the cytosol before it can be oxidized in the mitochondrion. If palmitate and radioactive [14C]coenzyme A are added to hepatocytes, palmitoyl-CoA isolated from the cytosolic fraction is radioactive, but that isolated from mitochondrial fraction is not. Explain

Compartmentation in ß oxidation. Free palmitate is activated to its coenzyme A derivative (palmitoyl-CoA) in the cytosol before it can be oxidized in the mitochondrion. If palmitate and radioactive [14C]coenzyme A are added to hepatocytes, palmitoyl-CoA isolated from the cytosolic fraction is radioactive, but that isolated from mitochondrial fraction is not. Explain

Chemistry for Today: General, Organic, and Biochemistry

9th Edition

ISBN:9781305960060

Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Chapter23: Carbohydrate Metabolism

Section: Chapter Questions

Problem 23.82E

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