Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Compartmentation in ß oxidation. Free palmitate is activated to its coenzyme A derivative
(palmitoyl-CoA) in the cytosol before it can be oxidized in the mitochondrion. If palmitate and
radioactive [14C]coenzyme A are added to hepatocytes, palmitoyl-CoA isolated from the
cytosolic fraction is radioactive, but that isolated from mitochondrial fraction is not. Explain
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Transcribed Image Text:Compartmentation in ß oxidation. Free palmitate is activated to its coenzyme A derivative (palmitoyl-CoA) in the cytosol before it can be oxidized in the mitochondrion. If palmitate and radioactive [14C]coenzyme A are added to hepatocytes, palmitoyl-CoA isolated from the cytosolic fraction is radioactive, but that isolated from mitochondrial fraction is not. Explain
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