Compare and contrast the location and pH sensitivity of receptor-ligand interaction in the LDL and transferrin receptor-mediated endocytosis pathways.

Q: Describe the consequences of ER-lumenal accumulation of damaged or misfolded proteins in a…

A: The endoplasmic reticulum is considered to be the main site for protein synthesis. Maturation of…

Q: Using examples, describe the signalling pathway from receptor tyrosine kinase activation to gene…

A: Many polypeptide growth factors, cytokines, and hormones have high-affinity cell surface receptors…

Q: a. Panels G, H, and I show pattters wher fluorescence is detected in the cytosol or internal…

A: In the panels G, H, and I, the same β5 subunit of G protein is associated with different γ subunits.…

Q: Which describes the enzymatic activity/biochemical function of dynamin? Answers: bind to and…

A: A protein called dynamin is necessary for both clathrin-mediated endocytosis and synaptic vesicle…

Q: Select the best explanation of the unfolded protein response (UPR): O A. The UPR senses misfolded…

A: When the protein is completely formed it is folded accordingly yo form a biologically active protein…

Q: Explain the steps associated with translocation of ER proteins across the ER membrane.

A: The Endoplasmic reticulum(ER) plays an important role and it would be the place where the membranes…

Q: What is a secondary transporter? Why are they called secondary?  What is [3 H]Leu? Explain both 3H…

A: It is a type of active transport. It falls across a biological membrane. Here a transporter protein…

Q: Binding of PGI2 to its protein binding receptor leads to

A: Prostacyclin (PGI2) is basically generated in the mammalian vasculature with increased levels in the…

Q: Enumerate SRP binding molecules and indicate the function elicited by each binding AND Explain the…

A: Signal sequence  - slowing of protein synthesis ( elongation arrest ) :…

Q: Which of the following protein domains would you expect to find in an "easily druggable" target b…

A: * protein domain is a part of protein sequence and tertiary structure that can  function and evolve…

Q: Define SCF-proteasomedegrades phosphorylatedS phase CDK inhibitor

A: Misregulation of any aspect of the cell cycle may lead to developmental defects and diseases such as…

Q: Describe in detail how a tryptophan attenuator iscontrolled

A: Step 1  A repressible operon system is a positively regulated segment of genetic material which…

Q: State the function and desired products of the hexose monophosphate shunt pathway.

A: Cells metabolize glucose molecules through the glycolytic pathway to release the energy required for…

Q: How would a dominant-negative Arf1 protein affect (or not) the following processes.…

A: Arf1 is a small GTPase that is involved in vesicular transport. It has been shown to play a role in…

Q: Name four different proteins that facilitate the modification or folding of secretory proteins…

A: Several proteins facilitate the modification or folding of secretory proteins within the ER. These…

Q: Based on the UCP1 protein structure and the figure above, what are the likely chemical properties of…

A: UCP 1 protein: The UCP1 (uncoupling protein 1) protein is a mitochondrial protein found in brown…

Q: Which of the proteins: the CAP or the lac repressor, does the eukaryotic nuclear receptor for the…

A: There are steroid hormones (compounds with characteristic sterol rings). Steroid hormones can be…

Q: Cholera is an acute, diarrheal disease caused by infection of the intestine with the gram-negative,…

A: Proteins are high molecular weight biomolecules made up of amino acid residues linked via peptide…

Q: About the role of Ran-GAP and Ran-GEF for the unidirectional transportation of the cargo proteins…

A: Ran is a nuclear protein that is related to RAS and is also known as a GTP-binding nuclear protein.…

Q: How we can use Dexamethasone in the context of COVID 19? What is the mechanism? As a pharmacist why…

A: Approach to solving the question: Detailed explanation: Examples: Key references: Health Science

Q: Receptor-mediated endocytosis is a multistep process that allows relatively large…

A: Hypocholesteremia is high plasma cholesterol levels which is seen as a result of an increase in the…

Q: Which describes an enzymatic activity/biochemical function of importin-beta?     facilitate…

A: Introduction : Importin beta are known as a type of karyopherin proteins which mediates the…

Q: Describe the steps that occur during the cotranslational sorting ofproteins to the endoplasmic…

A: Translation of an ER signal sequence that binds to the Signal Recognition Particle specifies…

Q: Most mammalian cells have a single immobile cilium called the primary cilium, in which…

A: Intraflagellar transport (IFT) is the process by which proteins are transported into cilia. It…

Q: One form of anemia results when individuals have a deficiency in the enzyme phosphatidylinositol…

A: Complement decay-accelerating factor (CD55 or DAF) is a protein that is transcribed and translated…

Q: In response to a hormone secreted by a cell of the opposite mating type, a yeast cell undergoes a…

A: GPCR (G Protein-Coupled Receptors) are cell surface receptors that use guanine nucleotide-binding…

Q: create a simple flowchart depicting the MC1R pathway

A: MC1R is a G protein-coupled receptor.

Q: Describe the steps that need to occur for the glucocorticoid receptor to bind to a GRE.

A: Glucocorticoids can be defined as the are hormones that are essential for life and their synthesis…

Q: Briefly explain how heme regulates the expression of globin genes in cells that synthesize…

A: Hemoglobin synthesis are global production and heme synthesis. Globin chain production occurs in the…

Q: Define quorum sensing and provide examples of cellular processes regulated by quorum sensing

A: Bioluminescence is the process of generation and emission of light(chemiluminescence) by a living…

Q: summarize the role of galactose, GAL80, GAL4, GAL3 in relation to upstream activator sequence

A: An upstream activating sequence:It is also known as upstream activation sequence or UAS. It is a…

Q: The affinity of integrins for matrix components canbe modulated by changes to their cytoplasmic…

A: Introduction: There are two pathways that are responsible for activation of integrin: 1. Inside out…

Q: In the absence of tension, MscL channel has an energy gap separating the closed and open states Eo =…

A: introduction Membrane-embedded mechanosensitive (MS) proteins are essential for varied biological…

Q: Give only typing answer with explanation and conclusion For the genotype shown below, which best…

A: Operon is the prokaryotic gene regulatory system or mechanism that regulates the expression of…

Q: List three examples of commonly employed combination of ligand and protein in affinity chromat

A: Affinity chromatography is a specific type of technique in which proteins are purified in a highly…

Q: Give Major Mechanisms by Which an Increase in Cytosolic Ca21 Concentration Induces the Cell’s…

A: Calcium ion (Ca2+) concentrations in the cytoplasm are generally kept at about 100 nM at rest. This…

Q: If you were to remove the ER retrieval signal fromprotein disulfide isomerase (PDI), which is…

A: We got the information of first type in carboxyl terminus of soluble ER proteins and in golgi…

Q: Describe the action of the following molecular playersin signal transduction pathways: growth…

A: Signal transduction pathway consists of series of molecular events happening in a cell in which…