Compare and contrast the location and pH sensitivity of receptor-ligand interaction in the LDL and transferrin receptor-mediated endocytosis pathways.

Briefly explain in your words the role of how Inside-out signaling of integrin occurs?

Explain Why when cellular signals shift in balance toward pro-apoptotic proteins, the cell is more likely to undergo apoptosis.

Give typing answer with explanation and conclusion to all parts  The pharmaceutical (−)-trans-Δ9-tetrahydrocannabinol (THC) is a metabolite that is biosynthesized specifically the glandular trichome cells of the plant species Cannabis sativa. The gene that catalyzes that last step in THC biosynthesis, namely THC ACID SYNTHASE (THCAS), is expressed exclusively in the glandular trichome cells of the plant and no other cell types. Given that all cell types arise from stem cells that have identical DNA, explain how glandular trichome cells develop unique morphology and why THCAS is expressed exclusively in that cell type.