Cancer by somatic translocation (a) Relocation of an oncogene next to a novel regulatory element: Burkitt lymphoma RegMYC MYC Chr 8 Translocation Regle break point IG Chr 14 Regla MYC Translocation (b) Formation of a hybrid oncogene: chronic myologenous leukemia ABL Chr 9 Translocation break point Chr 22 BCR1 Hybrid oncogene Translocation FIGURE 17-35 The two main ways that translocations can cause cancer in a body (somatic) cell are illustrated by the cancers Burkitt lymphoma (a) and chronic myelogenous leukemia (b). The genes MYC, BCR1, and ABL are proto-oncogenes.
Cancer by somatic translocation (a) Relocation of an oncogene next to a novel regulatory element: Burkitt lymphoma RegMYC MYC Chr 8 Translocation Regle break point IG Chr 14 Regla MYC Translocation (b) Formation of a hybrid oncogene: chronic myologenous leukemia ABL Chr 9 Translocation break point Chr 22 BCR1 Hybrid oncogene Translocation FIGURE 17-35 The two main ways that translocations can cause cancer in a body (somatic) cell are illustrated by the cancers Burkitt lymphoma (a) and chronic myelogenous leukemia (b). The genes MYC, BCR1, and ABL are proto-oncogenes.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Based on Figure 17-35, write a sentence stating how
translocation can lead to cancer. Can you think of another genetic cause of cancer?
Transcribed Image Text:Cancer by somatic translocation
(a) Relocation of an oncogene next to a novel regulatory element: Burkitt lymphoma
RegMYC
MYC
Chr 8
Translocation
Regle break point
IG
Chr 14
Regla
MYC
Translocation
(b) Formation of a hybrid oncogene: chronic myologenous leukemia
ABL
Chr 9
Translocation
break point
Chr 22
BCR1
Hybrid oncogene
Translocation
FIGURE 17-35 The two main ways that translocations can cause cancer in a body
(somatic) cell are illustrated by the cancers Burkitt lymphoma (a) and chronic myelogenous
leukemia (b). The genes MYC, BCR1, and ABL are proto-oncogenes.
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