Can you show me how to solve this Experiment 3: Wet granulation Rx Calcium carbonate 135 mg Sig. Prepare 5 tablets Magnesium carbonate 100 mg Sodium chloride 50 mg 10% Starch paste qs Magnesium stearate 1% Dried cornstarch 1% * The prescription is to be prepared as follows: 1. Prepare the 10% starch paste by making a slurry with a small amount of water. To this slurry, add boiling water to the final volume and stir until a translucent gel has formed. 2. In a mortar, blend the calcium carbonate, magnesium carbonate and sodium chloride. Gradually with kneading and mixing, add the starch paste until a mass is formed that will ball and stick together when squeezed, but will not be sticky and gummy. 3. Pass this mass through sieve # 40 and collect on a paper-lined tray. Dry the granulation in the oven set at 55 degrees Celsius then pass through sieve #40 again then weigh. 4. Calculate the weight of lubricant to be added (mixture equal amounts of dried cornstarch and magnesium stearate) then blend. 5. Package in a tight container and label. Question 1: Enlarge the formulation to make 5 tablets. Show your complete handwritten solution (please insert a clear and well-lit image on the space provided; no reference required) to justify your answer.

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
Question

Can you show me how to solve this

Experiment 3: Wet granulation

Rx Calcium carbonate 135 mg Sig. Prepare 5 tablets
Magnesium carbonate 100 mg
Sodium chloride 50 mg
10% Starch paste qs
Magnesium stearate 1%
Dried cornstarch 1%
* The prescription is to be prepared as follows:

1. Prepare the 10% starch paste by making a slurry with a small amount of water. To this slurry, add boiling water to the final volume and stir until a translucent gel has formed.
2. In a mortar, blend the calcium carbonate, magnesium carbonate and sodium chloride. Gradually with kneading and mixing, add the starch paste until a mass is formed that will
ball and stick together when squeezed, but will not be sticky and gummy.
3. Pass this mass through sieve # 40 and collect on a paper-lined tray. Dry the granulation in the oven set at 55 degrees Celsius then pass through sieve #40 again then weigh.
4. Calculate the weight of lubricant to be added (mixture equal amounts of dried cornstarch and magnesium stearate) then blend.
5. Package in a tight container and label.

Question 1: Enlarge the formulation to make 5 tablets. Show your complete handwritten solution (please insert a clear and well-lit image on the space provided; no
reference required) to justify your answer.

Expert Solution
steps

Step by step

Solved in 3 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY