
Chemistry: Principles and Practice
3rd Edition
ISBN: 9780534420123
Author: Daniel L. Reger, Scott R. Goode, David W. Ball, Edward Mercer
Publisher: Cengage Learning
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Can someone help me identify if these structures have R or S configurations?

Transcribed Image Text:**Title: Assigning Absolute Configuration of Chirality Centers**
**Objective:**
Identify the absolute configuration of the chirality centers in each of the following compounds as R or S. If multiple chirality centers are present, indicate the stereochemical designations as: RR, SS, RS, or SR.
*Note: Other terms used for chirality center include chiral center, stereocenter, and stereogenic center.*
### Compounds:
1. **First Compound:**
**Structure:**
- The molecule contains a cyclopropane ring.
- Two chlorine (Cl) atoms are attached to the cyclopropane, one with a wedge (indicating it is pointing out of the plane towards the viewer) and the other with a dashed line (indicating it is pointing behind the plane).
**Task:**
- Determine the absolute configuration (R or S) for the chiral center with two chlorine atoms.
2. **Second Compound:**
**Structure:**
- The molecule is a linear carbon chain with an OH group and a methyl (CH₃) group.
- The OH group is represented with a wedge, while the hydrogen atom (H) is represented with a dashed line, both attached to the same carbon.
**Task:**
- Determine the absolute configuration (R or S) for the chiral center with the hydroxyl group and methyl group.
3. **Third Compound:**
**Structure:**
- The molecule is a cyclohexane ring with two substituents: a methyl group and a hydroxyl group.
- The OH group is represented with a wedge.
**Task:**
- Determine the absolute configuration (R or S) for the chiral center with the hydroxyl group.
### Conclusion
Each compound requires analysis of the spatial arrangement of groups around the chiral centers, following the Cahn-Ingold-Prelog priority rules to assign the R or S configuration appropriately. Once configurations are identified, combinations like RR, SS, RS, or SR can be determined for compounds with multiple chiral centers.
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