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- In cholinergic neurotransmission, inhibition of the choline transporter will affect the normal synthesis and release acetylcholineTRUE OR FALSEIdentify the structure highlighted in green: Epinephrine receptor ACh receptor Norepinephrine receptorDepending on the size and complexity of the molecule, small chemical alterations can impart significant activity differences, especially if a certain part of the molecule is critical for binding. Considering this, select structure(s) below that are expected to have high cholinergic agonist activity based on what we leamed about acetylcholine's SAR.
- Endocrine Ligand acting on intracellular receptor should be: O Hydrophilic O Hydrophobic O Amphipathic O Macromolecule What kinds of molecules may pass throughShown are different derivatives of acetylcholine. A H2N H2N D 1. Which one is expected to lose its ability to bind to the receptor but could elicit CNS side effects? Explain. 2. Which is/are expected to resist metabolism by choline esterase? 3. Which one is not expected to bind and yet prone to metabolism? Explain ZIPart A Which of the following statements about pain-relief substances is correct? View Available Hint(s) O Endorphins are synthetic pain-killers. O Met-enkephalin has pain-killing ability because of its structural similarity to morphine. O Many natural pain-killing polypeptides are ideal for medical use. O Receptors of opium derivatives are found in all body cells. Submit
- Catecholamines like epinephrine and norepinephrine among having many physiological effects like increased blood pressure, on a molecular level will also promote the breakdown of what?Substrates for MAO (monoamine oxidase) include monoaminergio neurotransmitters cuch as catecholamines like dopamine (see image below): Н. NH2 HO Which do you think ls an Inhibitor for MAO? *NH2 Option 1 Option 2 don Option 3 Baced on the anower above, what type of Inhibitor le it? CompatitiveVitamins B1, B6 and B12 are so-called "Neurotropic" vitamins. They may response to "Wallerian degeneration" in nerve system. Briefly describe"Wallerian degeneration" and how the "neurotropic" vitamins react with this process.
- "Mechanism of analgesic action of morphine"-Briefly explain this statement. explain at your own wordsTo maximize the activity of an α4β2 nicotinic Achtylchcholine Receptor (nAChR), how many agonist binding sitea should be occupied?The structures of norepinephrine and epinephrine differ by a single methyl group . Knowing what you know about amino acid and protein structure, propose what differences in protein structure would allow norepinephrine to bind with higher affinity to the b1- how epinephrine binds with higher affinity to the b2-adrenergic receptor.
