Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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A reactive nucleotide building block obtained by the reaction (9) which occurs in the presence of a weak base diisoprpylethlamine. Write down a detailed mechanism for the reaction 9
(Bz-)
Meo
NH.
Polystyrene
HN
Meo
-Leu-Pro-N
(DMT--)
(21)
CCl;CO2H
[10]
(22)
(23) (20)
chemical catalyst
Bz.
NH
BZNH
[9]
DMTr-O,
DMTr-O.
OCH2CH2CN,
iPr,NEt
HO
iPr2N
OCH,CH,CN
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Transcribed Image Text:(Bz-) Meo NH. Polystyrene HN Meo -Leu-Pro-N (DMT--) (21) CCl;CO2H [10] (22) (23) (20) chemical catalyst Bz. NH BZNH [9] DMTr-O, DMTr-O. OCH2CH2CN, iPr,NEt HO iPr2N OCH,CH,CN
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