Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Brown and Goldstein won the Nobel Prize for discovering the molecular basis of familial hypercholesterolemia (FH). The key experiment that led to the breakthrough was that cells from FH patients responded to LDL by increasing cholesterol biosynthesis.
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