Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug: the herbal medicine St John’s wort, classified as an “inducer of CYP3A4” in the AMH; grapefruit juice, classified as an “inhibitor of CYP3A4” in the AMH.
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Your allocated drug is Paclitaxel, which is listed as a “CYP3A4 substrate” in the Australian Medicines Handbook (AMH).
Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug:
the herbal medicine St John’s wort, classified as an “inducer of CYP3A4” in the AMH;
grapefruit juice, classified as an “inhibitor of CYP3A4” in the AMH.
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