Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug:   the herbal medicine St John’s wort, classified as an “inducer of CYP3A4” in the AMH; grapefruit juice, classified as an “inhibitor of CYP3A4” in the AMH.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter9: Parenteral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 16SST
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Your allocated drug is Paclitaxel, which is listed as a “CYP3A4 substrate” in the Australian Medicines Handbook (AMH).

 

Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug:

 

the herbal medicine St John’s wort, classified as an “inducer of CYP3A4” in the AMH;

grapefruit juice, classified as an “inhibitor of CYP3A4” in the AMH.

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