Which of the below statements are FALSE?I: Cholesterol synthesis is regulated by covalent modification of HMG-COA reductaseII: Inhibition of ACAT mediated increase in esterification of cholesterol estersIII: Transcriptional regulation of the LDL particle regulates cholesterol synthesisIV: Squalene is a cholesterol precursorV: All the carbons in cholesterol comes from acetyl-CoAO A. I, IIO B. II, VO C. II, IIO D.I, IV

Cholesterol synthesis: The synthesis of cholesterol takes place in all tissues. The major sites of…

Answered: Which of the below statements are…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter18: Glycolysis

Section: Chapter Questions

Problem 20P: Understanding the Mechanism of Hemolytic Anemia Genetic defects in glycolytic enzymes can have...

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Which of the below statements are FALSE? I: Cholesterol synthesis is regulated by covalent modification of HMG-CoA reductase II: Inhibition of ACAT mediated increase in esterification of cholesterol esters III: Transcriptional regulation of the LDL particle regulates cholesterol synthesis IV: Squalene is a cholesterol precursor V: All the carbons in cholesterol comes from acetyl-CoA A. I, III B. II, V C. II, III D. I, IV
Which one of the following will function to inhibit CPT1? A.palmitoyl-CoA B.citrate C propionyl-CoA D.acetyl-CoA E malonyl-CoA
A. Elastase is activated by trypsinB. Trypsinisactivatedbyelastase Which statement is correct? Proteolytic activation of chymotrypsin from chymotrypsinogen requires cleavage of four peptide bonds. Assume that any proteases can convert 100 substrates to 100 products. Activation of one enteropeptidase can eventually lead to formation of how many chymotrypsin proteins?
All of the following are true with respect to alpha-glucosidase inhibitor, except:A. It inhibits intestinal alpha-glucosidase B. It decreases enzymatic conversion of oligo- to monosaccharidesC. It lowers postprandial glucoseD. It causes gastrointestinal disturbances.E. It may cause development of hypertension.
A patient who has been drinking large amounts of alcohol for long periods of time shows thefollowing symptoms: apathy, loss of memory, and a rhythmical to-and-fro motion of the eyeballs.Which of the following reactions are most likely to be affected in the patient? A. Conversation of pyruvate to acetyl-CoA B. Conversation of a-ketoglutarate to succinyl-CoA C. Both A and B D. Neither A nor B
Which of the following pairs of lipid-soluble vitamin:function is/are WRONG? Vit K:synthesis of Ca-binding proteins for blood clotting U Vit C:anti-oxidant Vit E:remove free radicals Vit D:regulation of Ca and P metabolism Vit A:site of photochemical reaction in vision
In the metabolism of lipids, B-oxidation will yield (n/2) acetyl-CoA fragments from a C fatty acid. Fatty acids with an odd number of carbons are also metabolized by B-oxidation to acetyl-CoA fragments. However, the final fragment is a. propionyl-COA O b. succinyl-CoA O c. Oxaloacetate O d malonyl-COA O e glyceraldehyde-3-phosphate
v Hydroxy methyl glutaryl coA Match the following metabolites with the correct metabolic pathway v Propionyl-CoA A. Kreb's cycle v Dihydroxy acetone phosphate B. Soluble fiber fermenta v succinyl co-A C. Cholesterol synthesis v Hydroxy methyl glutaryl coA D. glycolysis v Hydroxy-butyrate E. Beta oxidation
High levels of acetyl-CoA could be an indication of excess A. Arg, Glu, Ile B. Lys, Tyr, Trp C. Phe, Tyr, Ile D. Thr, Tyr, Ala
Define the following terms: a. thiolytic cleavage b. ketogenesis c. ketone bodies d. α-oxidation e. ACC
Before a fatty acid can undergo B-oxidation it must be: O Transport of the FA into the mito. matrix O Hydrolysis of the carboxyl group from the FA O Carboxylation of Acetyl-CoA to form malonyl-CoA Activation of the FA with Coenzyme A O Oxidation of the FA yielding a A2-enoyl intermediate
Order the steps that results in a triacylglycerol containing two palmitic acids and one stearic acid. a. Diacylglycerol reacts with an fatty-acyl-CoA b. Phosphate is remove from phosphatidic acid to form diacylglycerol c. Two of the fatty acyl-CoAs react with glycerol-3-phosphate d. An elongase produce stearic acid e. Stearoyl-CoA is synthesized…

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