7. Heparin is a complex polysaccharide, a component of protcoglycans. Isolated heparin used as an anticoagulant, binds to the protcin antithrombin and inhibits clot formation. As lipoprotein lipase is bound to the capillary endothelium through proteoglycan, heparin also can bind to LP lipase and dislodge it from the capillary wall. Why such treatment results in increased levels of triacylglycerols in blood? For the answer: a) draw the scheme representing the function of LP- lipase; b) indicate the activator of this enzyme; c) explain the mechanism of hypertriacylglycerolemia development in the patient.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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7. Heparin is a complex polysaccharide, a component of protcoglycans. Isolated
heparin used as an anticoagulant, binds to the protcin antithrombin and inhibits
clot formation. As lipoprotein lipase is bound to the capillary endothelium
through proteoglycan, heparin also can bind to LP lipase and dislodge it from the
capillary wall. Why such treatment results in increased levels of triacylglycerols
in blood? For the answer:
a) draw the scheme representing the function of LP- lipase;
b) indicate the activator of this enzyme;
c) explain the mechanism of hypertriacylglycerolemia development in the
patient.
Transcribed Image Text:7. Heparin is a complex polysaccharide, a component of protcoglycans. Isolated heparin used as an anticoagulant, binds to the protcin antithrombin and inhibits clot formation. As lipoprotein lipase is bound to the capillary endothelium through proteoglycan, heparin also can bind to LP lipase and dislodge it from the capillary wall. Why such treatment results in increased levels of triacylglycerols in blood? For the answer: a) draw the scheme representing the function of LP- lipase; b) indicate the activator of this enzyme; c) explain the mechanism of hypertriacylglycerolemia development in the patient.
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