Based upon the following image of imatinib bound to BCR-ABL, which of the following mutations would result in the largest reduction in imatinib binding? Phe317 ☆ Tyr253 A. Phe317-Tyr B. Tyr253 Phe C. Thr315-lle D. lle313-Leu E. Phe359-Tyr Thr315 Phe382 Ile313 Met290 Glu286 Asp381 His361 Phe359

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