Based upon the following image of imatinib bound to BCR-ABL, which of the following mutations would result in the largest reduction in imatinib binding? Phe317 ☆ Tyr253 A. Phe317-Tyr B. Tyr253 Phe C. Thr315-lle D. lle313-Leu E. Phe359-Tyr Thr315 Phe382 Ile313 Met290 Glu286 Asp381 His361 Phe359

Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
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Based upon the following image of imatinib bound to BCR-ABL, which of the following mutations would result in the
largest reduction in imatinib binding?
Phe317
☆
Tyr253
A. Phe317 Tyr
B. Tyr253 Phe
C. Thr315→lle
D. lle313 Leu
E. Phe359-Tyr
Thr315
A
Phe382
Ile313
Met290
Glu286
Asp381
His361
#
Phe359
Transcribed Image Text:Based upon the following image of imatinib bound to BCR-ABL, which of the following mutations would result in the largest reduction in imatinib binding? Phe317 ☆ Tyr253 A. Phe317 Tyr B. Tyr253 Phe C. Thr315→lle D. lle313 Leu E. Phe359-Tyr Thr315 A Phe382 Ile313 Met290 Glu286 Asp381 His361 # Phe359
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