Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Short Answer 2. You are studying the role of Kinase A and CDKI in neuroblastoma, a type of cancer. In neuroblastoma tumors, mutations are found in genes for both Kinase A and CDKI. CDKİ is a cell cycle inhibitor, and phosphorylation of CDKI by Kinase A will inhibit the normal function of CDKİ, as diagrammed below. Wild type Kinase A activates mitosis Wild type CDKİ inactivates mitosis Wild type Kinase A can inactivate CDKI H= Inhibits CDKI Kinase A Mitosis G1 G2 S-phase
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Transcribed Image Text:Short Answer 2. You are studying the role of Kinase A and CDKI in neuroblastoma, a type of cancer. In neuroblastoma tumors, mutations are found in genes for both Kinase A and CDKI. CDKİ is a cell cycle inhibitor, and phosphorylation of CDKI by Kinase A will inhibit the normal function of CDKİ, as diagrammed below. Wild type Kinase A activates mitosis Wild type CDKİ inactivates mitosis Wild type Kinase A can inactivate CDKI H= Inhibits CDKI Kinase A Mitosis G1 G2 S-phase
B) If a tumor-promoting mutation in the gene that codes for Kinase A generates an always active Kinase A protein, what type of mutation (gain of function or loss of function)? Explain.
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Transcribed Image Text:B) If a tumor-promoting mutation in the gene that codes for Kinase A generates an always active Kinase A protein, what type of mutation (gain of function or loss of function)? Explain.
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