At equilibrium, Rage2 in normal humans exhibits 115 times more folded than unfolded forms. Normally, it has an alanine in the hydrophobic core but in zombies this residue is mutated to a serine. In the core, the serine mutant loses one hydrogen bond (AG°h-bond = -1.4kcal/mol). What is AG°folding for the ala ser mutant? What is the net effect of this mutation for protein folding?

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
Question
None
At equilibrium, Rage2 in normal humans exhibits 115 times more folded than unfolded
forms. Normally, it has an alanine in the hydrophobic core but in zombies this residue is mutated to
a serine. In the core, the serine mutant loses one hydrogen bond (AG°h-bond = -1.4kcal/mol). What is
AG°folding for the ala ser mutant? What is the net effect of this mutation for protein folding?
Transcribed Image Text:At equilibrium, Rage2 in normal humans exhibits 115 times more folded than unfolded forms. Normally, it has an alanine in the hydrophobic core but in zombies this residue is mutated to a serine. In the core, the serine mutant loses one hydrogen bond (AG°h-bond = -1.4kcal/mol). What is AG°folding for the ala ser mutant? What is the net effect of this mutation for protein folding?
Expert Solution
steps

Step by step

Solved in 2 steps with 1 images

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY