At age 6 months an infant is diagnosed with a form of epilepsy characterised by sudden onset of head-drop seizures and deteriorating mental development. Discuss the normal function of the blood brain barrier, the type of epilepsy in this case and explain how a leaky blood brain barrier might lead to seizures being triggered. Include in your answer possible treatment options for the infant.

Link:     https://doi.org/10.1186/s12868-022-00692-1  A. In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “In Fig. 4, the demyelination of (A-C) the cerebellum and (F-H) brain stem was evaluated using LFB staining and median scored 2.5 in both sedentary and exercised untreated EAE rats indicating extensive demyelination.”  Why was demyelination evaluated in this study?   B. In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “Post-administration of mitoxantrone to sedentary and exercised groups smaller patches of demyelination with microcyst formation and lymphocytic infiltrates were seen; and bare unmyelinated axons were fewer (Figs. 3D, E, I, J and 4D, E, I, J).”  Based on this quote, what is mitoxantrone doing exactly/directly?

Please draw the components of the cerebrum and cerebellum along with the white matter of the two structures. Please draw the cortex and point to the gray and white matter in both the cerebellum and cerebrum.  Thank you.

What are meninges? Discuss each meninge layer that covers the brain. Thank you.