Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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### Understanding pH-Log Solubility Profiles

#### Graph Analysis:
The graph titled "pH-log solubility" shows the relationship between pH levels (x-axis) ranging from 0 to 14 and the log solubility of a drug (y-axis) ranging from 0 to 5. The curve indicates how solubility changes with pH.

- **Interpretation of the Curve**:
  - The curve starts at a high log solubility of around 5 at pH 0.
  - As pH increases from 0 to about 6, the solubility decreases sharply.
  - Beyond pH 6, the curve levels off, indicating little change in solubility at higher pH values.

#### Questions and Answers:

15. **What type of drug classification can be assumed for a drug that demonstrates this type of pH-solubility profile?**
   - a. WA (Weak Acid)
   - b. WB (Weak Base)
   - c. NE (Neutral)

16. **What is the approximate pKa of this drug?**
   - a. 2
   - b. 6
   - c. 10
   - d. 12

17. **What is the log \( S_0 \) for this drug?**
   - a. 0.7
   - b. 1.4
   - c. 3.2
   - d. 4.3

This information can help in understanding the solubility behavior of drugs in different pH environments, which is crucial for formulation and drug delivery considerations.
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Transcribed Image Text:### Understanding pH-Log Solubility Profiles #### Graph Analysis: The graph titled "pH-log solubility" shows the relationship between pH levels (x-axis) ranging from 0 to 14 and the log solubility of a drug (y-axis) ranging from 0 to 5. The curve indicates how solubility changes with pH. - **Interpretation of the Curve**: - The curve starts at a high log solubility of around 5 at pH 0. - As pH increases from 0 to about 6, the solubility decreases sharply. - Beyond pH 6, the curve levels off, indicating little change in solubility at higher pH values. #### Questions and Answers: 15. **What type of drug classification can be assumed for a drug that demonstrates this type of pH-solubility profile?** - a. WA (Weak Acid) - b. WB (Weak Base) - c. NE (Neutral) 16. **What is the approximate pKa of this drug?** - a. 2 - b. 6 - c. 10 - d. 12 17. **What is the log \( S_0 \) for this drug?** - a. 0.7 - b. 1.4 - c. 3.2 - d. 4.3 This information can help in understanding the solubility behavior of drugs in different pH environments, which is crucial for formulation and drug delivery considerations.
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