Bone Matrix Composition The bony matrix is a mineralized connective tissue composed of organic and inorganic components that allow for strength as well as a degree of flexibility. The organic component of bone is collagen, which allows for resilience and flexibility of rigid bony tissue. The inorganic components to bone are mineralized salts such as calcium carbonate and calcium phosphate and allow for rigidity and strength. This experiment observes how the physical properties of bone change when the properties of its matrix are altered. Soaking bone in acetic acid (vinegar) dissolves out the mineral salts and heating bone denatures and removes the fibrous protein (collagen). Examine a chicken bone that has been soaked in acetic acid (vinegar), one that has been baked and an untreated bone. Record your observations regarding hardness and flexibility in Table 7.2. Identify what is missing or has been degraded (organic vs. inorganic matrix) due to the treatment. Table 7.2. Effect of treatments on bony matrix. Bone Observations What is missing? Soaked Baked Untreated 175

For Total knee prothesis, Titanium,Aluminimum, vanadium and NE how are this material suitable for implantation?

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24. A rare genetic disorder called receptor deficit rickets results in the absence of a working receptor for the active form of Vitamin D in tissues. This lack of receptor results in the "message" of vitamin D being lost. What impacts on bone formation would you predict from this disorder? (check all that apply) Group of answer choices fewer materials for building bone would be delivered via the nutrient artery upregulation of Ca+2 transporters would be limited Ca+2 absorption would be impacted bone density would be decreased chondrocytes would be prevented from creating an alkaline environment osteoclast activity would be suppressed, limiting remodeling