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- In addition to the many pharmaceutical products available to treat various diseases, there are also many “natural remedies” that may treat the same diseases, though they do not have FDA approval. For example, Dramamine was developed to treat nausea, but many tout ginger as an effective remedy for nausea. Despite the potential of these natural remedies, pharmaceutical companies do not invest in the development of these natural remedies to obtain FDA approval. Explain why this is the case, and what might be a potential solution to this underinvestment.What is DPI? What are the advantages of DPI over MDI? How drug is aerosolized from a DPI system? Please answer at your own words.what is pharmacophore? what is the importance of pharmacophore in drug discovery?
- A pathogenic bacteria ferments for survival in your patient producing a swollen, dark discolored leg due to muscles degradation and gas-filled distension on the skin. Treatment includes pressurized hyperbaric oxygen. Which of the following apply? None of the statements apply Streptococcus pneumoniae causing community aquired pneumonia. Klebsiella pneumoniae causing cellular degradation in pulmonary tissues Clostridium perfringens causing gas gangrene resulting in myonecrosis by synthesis of acids and gases Staphylococcus aureus producing lipases and proteasesBelow, you can see a picture of an antimicrobial drug. Regarding semi-synthetic antimicrobial drug development to try to avoid development of antibiotic resistance, use 1 sentence to address what is the significance/value of the presence of the various R-groups (e.g. R4, R5, R6, etc.)?What specific biological compound(s) present in moringa oleifera leaves is/are responsible for its anti-microbial properties? You may refer to this article: https://www.frontiersin.org/articles/10.3389/fphar.2018.00108/full#T5
- Which ONE of the following best describes ciprofloxacin? Select one: A. Active against Streptococcus pneumoniae B. An inhibitor of RNA synthesis C. An antimicrobial prodrug D. A natural product produced by Streptomyces spp. E. Subject to new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effectsWhat is the difference between the use of Peppermint oil and Cinnamon oil in Veterinary Medicine to treat the bacterial infections Escherichia coli and Staphylococcus?The type of antimicrobial drug that would be most likely to have toxic effects in humans based on the premise of selective toxicity when treating microbial infection would be a drug that O 1) inhibits the synthesis of the cell wall O 2) inhibits metabolic pathways O 3) disrupts the cytoplasmic membrane 4) inhibits protein synthesis 5) All of the above have equal potential to be toxic
- The reason why most antibiotics as oral suspension dosage forms are commercially available as dry powders, to be reconstituted with water just prior to dispensing, is:With the aid of diagrams, illustrate the biochemical basis of the following: Allopurinol used in the management of gout Hydroxyurea as an antineoplastic agent 6-mercaptopurine, an anticancer agent Trimethoprim, an antibacterial agentDoris has reconstituted a bottle of Cefprozil® Oral Suspension to fill a patient's prescription. The prescription calls for 400 mg CefprozilⓇq12h for 7 days. Doris needs to know if the amount of reconstituted medication in the bottle will be enough to last the patient for 7 days. Calculate the total amount of medication in the bottle after this medication has been reconstituted: TEVA Seferle, PA 18960 PHARMACEUTICALS USA SHAKE WELL BEFORE USING KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN 5 mL (approx. one teaspoonful) of suspension. Phenylketonurics: This product contains 10.1 mg of phenylalanine per Store constituted suspension in refrigerator. Discard after 14 days Ruv. A 7/2005 L52974 NDC 0093-1075-78 CEFPROZIL for Oral Suspension USP 125 mg/5 mL* Each 5 mL, when constituted according to directions, contains 125 mg anhydrous cetprozil, Ronly 75 mL (when mixed) TEVA To the Pharmacist: Prepare suspension at time of dispensing. Add to the bottle a total of 59 ml water.…