A student working in a research lab is characterizing a form of elastase, where a valine that is normally in this elastase's substrate binding pocket has been changed to aspartate. How would the valine-to-aspartate mutation alter the KM for the enzyme? The valine-to-aspartate mutation would most likely increase the KM The valine-to-aspartate mutation would most likely decrease the KM. The valine-to-aspartate mutation would most likely not change the KM

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Chapter1: Chemical Foundations
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A student working in a research lab is characterizing a form of elastase, where a valine that is normally in this elastase's substrate binding pocket has
been changed to aspartate. How would the valine-to-aspartate mutation alter the KM for the enzyme?
The valine-to-aspartate mutation would most likely increase the KM
The valine-to-aspartate mutation would most likely decrease the KM.
The valine-to-aspartate mutation would most likely not change the KM
O O
Transcribed Image Text:A student working in a research lab is characterizing a form of elastase, where a valine that is normally in this elastase's substrate binding pocket has been changed to aspartate. How would the valine-to-aspartate mutation alter the KM for the enzyme? The valine-to-aspartate mutation would most likely increase the KM The valine-to-aspartate mutation would most likely decrease the KM. The valine-to-aspartate mutation would most likely not change the KM O O
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