A protein (P) binds a ligand (L) to form a complex (PL).a. Draw the equilibrium expression.b. Write the dissociation constant Ka, using [P], [L] or [PL], or some of them.c. Write the fraction bound of the ligand to the protein 0, using [P]. [L] or [PL], or some of them.d. From b and c, derive the equation of the fraction bound e in terms of [L] and Ka. Show the process.e. Sketch a hypothetical binding curve. Then, circlethe Ka value. Explain why you chose this (L].10-0.9-08-07-06-e 05-0.4-0.3-02-01-2550100150200

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A protein (P) binds a ligand (L) to form a complex (PL). a. Draw the equilibrium expression. b. Write the dissociation constant Ka, using [P], [L] or [PL), or some of them. c. Write the fraction bound of the ligand to the protein 8, using [P). (L] or [PL), or some of them.

A protein (P) binds a ligand (L) to form a complex (PL). a. Draw the equilibrium expression. b. Write the dissociation constant Ka, using [P], [L] or [PL), or some of them. c. Write the fraction bound of the ligand to the protein 8, using [P). (L] or [PL), or some of them.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

A protein (P) binds a ligand (L) to form a complex (PL).
a. Draw the equilibrium expression.
b. Write the dissociation constant Ka, using [P], [L] or [PL], or some of them.
c. Write the fraction bound of the ligand to the protein 0, using [P]. [L] or [PL], or some of them.
d. From b and c, derive the equation of the fraction bound e in terms of [L] and Ka. Show the process.
e. Sketch a hypothetical binding curve. Then, circle
the Ka value. Explain why you chose this (L].
10-
0.9-
08-
07-
06-
e 05-
0.4-
0.3-
02-
01-
25
50
100
150
200

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