A phenotypically normal boy has 45 chromosomes, but his sister, who has Down syndrome, has 46. Suggest an explanation that explains both children.

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.