A novel new method of peptide synthesis involves formation of an amide bond by reaction of an a-keto acid with an N-alkylhydroxylamine. Он R + Co2 + H20 R R' Draw curved arrows to show the movement of electrons in the following step of the reaction mechanism Arrow-pushing Instructions :0: :ö: c-ö: R H20 CO2 A R R H-A

The IUPAC name for the compound shown is CH₂-CH CH3-CH2-C-NH-CH3 NH CHO O N-methylpropionamide ON-methylpropanamide O 1-methylpropanamide O 2-butanamide

Carbonic anhydrase is an enzyme that catalyzes the conversion of carbon dioxide to bicarbonate ion. It is a metalloenzyme, with Zn2+ coordinated at the active site by three histidine side chains. Propose a mechanism for the reaction.

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כיו הרוesereםס Arrange the following compounds in the decreasing order of pKa values. OH OH OH CH;CH,CH,OH CH3-CH-CH2OH ČI ČH3 ÑO2 1 4 5 2 A 4,5,3,2,1 B 1,2,4,5,3 1,2,3,5,4 1,2,3,4,5

Metabolism of arginine produces urea and the rare amino acid ornithine. Ornithine has an isoelectric point close to 10.Propose a structure for ornithine

Identify the product in the following reaction. OH je je A) I CI 22 B) II OH pyridine C) III IV OH

5. One method to make N-glycosidic bond for uridine synthesis is the reaction between 1-amino-2,3,5-tri-O-benzoyl- D-ribose and B-ethoxy-N-ethoxycarbonylacrylamide. Propose a likely mechanism for the reaction. Bz0. NH₂ OBz OBz + Eto Eto ΝΗ O Bz0. OBz OBz ΝΗ OH™ H₂O uridine

MeO + [0] DME heat Hint: C₁1 H100 O Hint: One of the byproducts formed

CF 3- Celecoxib -SO2NH2 Do the following synthesis reactions. ŞO₂NH₂ NHNH2 A +