A newborn develops severe vomiting and symptoms of metabolic acidosis. Urinalysis results are positive for ketones and negative for glucose and other reducing substances. If the urine had an odor of “sweaty feet,” what metabolic disorder would be suspected? If the newborn were producing dark brown urine with a sweet odor, what disorder would be suspected? Would an MS/MS screen be helpful for the diagnosis?

Define uremia.

BIUA A- |= ==而带 2) Complete this additional activity: Examine the below graph, which was published in a research paper. The graph depicts the % prevalence of Urinary Tract Infections (UTIS) in males versus females of different age groups. Answer these 2 questions related to the figure: 1. What is the main conclusion of the data presented in the graph below? 2. Why do you think this happens? 18.0% OMale OFemale (N-35,019) Figure taken from Shengsheng Yu, Alex Z. Fu, Ying Qlu, Samuel S. Engel, Ravi Shankar, Kimberly G. Brodovlcz, Swapnl lapathak, Larry Radican, "Disease burden of urinary tract infections among type 2 diabetes melitus patlents in the U.S Journal of Diabetes and its Complications, Volume 28, Issue 5,2014 14.0% .....l 201 18-24 18-24 25-34 55-64 65-74 75+ Male IN=38.132) 2.4% 2.74 4.34 6.5 10.1 16.2% Upload a PDF or a word file with your answers to Blackboard: Lab#11> Submit your completed UTI activity here

Describe the appearance of cells when the following abnormalities are present: toxic granulation, Döhle bodies, hypersegmentation, Pelger-Huët anomaly, May-Hegglin anomaly, Chédiak-Higashi syndrome, Alder-Reilly inclusions, Ehrlichia, and abnormalities of mature granulocytes in body fl uids.

Kelly is a 36-year-old female who has a history of type 2 diabetes, several respiratory infections as a child, and two full-term pregnancies (5 and 7 years ago). Two days ago, she began feeling a burning sensation when urinating. Her pain is progressively getting worse. Kelly assumes that she has a urinary tract infection (UTI) and makes an appointment at her primary clinic to seek relief. Briefly List and describe 3 steps Kelly can take to prevent UTIs in the future.

In a typical enzyme-catalyzed reaction, what are the relative concentrations of reactants and products as compared to the enzyme concentration?

Keegan is a new admission to the hospital with chronic renal failure. Keegan was born with only one kidney, which had functioned completely normal until approximately 1 year ago. Last year he had elective plastic surgery and went into renal failure. Prior to this, Keegan worked full time as a banker and went to the gym about three times a week. Keegan is lactose intolerant. Keegan will be starting hemodialysis three times per week. MEDICAL PROFILE Age 42 Height 6 ft 1 in Weight 191 lbs. GFR 12 ml/min Albumin 2.1 gm/dl Potassium and Phosphorus levels elevated Blood Pressure 182/103 QUESTIONS 1. Why is Keegan’s potassium and phosphorus levels high? How will the dialysis affect these values? What are phosphate binders and would their use be appropriate for this patient?

A 6-year-old boy is brought to the physician by his mother because of intermittent upper abdominal pain during the past 5 weeks and a rash for 1 week. Vital signs are normal. Physical examination shows yellow nodules over the extensor surfaces of the upper extremities. There's hepatomegaly and tenderness on palpation of the epigastric region. Serum studies show an increased amylase activity, increased chylomicron concentration, and a markedly increased triglyceride concentration. 3 months after beginning a fat-restricted diet, his serum chylomicron and triglyceride concentration decreased significantly, and the skin lesions resolve. A deficiency of which of the following enzymes is the most likely cause of these findings? a. Acetyl-CoA carboxylase b. HMG-CoA lyase c. HMG-CoA reductase d. Hormone-sensitive lipase e. Lipoprotein lipase

Subject: Environmental Physiology True or false: Urine dilution by the loop of Henle is dependent on the length of the loop, being more diluted, the longer the loop.

Answer first question. What disorder is affecting this individual?