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A change in the axon membrane potential from -70 mV to -64 mV would be called a
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depolarization
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polarization
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- Assume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold.A common membrane-bound intermediary between the receptor and the effector protein within the plasma membrane is the __________________.A neuron responds to adequate stimulation with _______, a type of self-propagating signal.
- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)Which of the following combinations of spatial summation of postsynaptic potentials (PSP) would result in an action potential in a typical neuron? The voltage given for each PSP is measured as it reaches the axon hillock. Axon A EPSP 25 mV & axon B IPSP 10 mV Axon A IPSP 25 mV & axon B EPSP 10 mV Axon A IPSP 5 mV & axon B IPSP 5 mV Axon A EPSP 5 mV & axon B EPSP 5 mVAt the membrane of an axón, the action potential is -60 mV for K+ ions. Calculate the external and internal concentration ratios.
- Hyperpolarization of a graded potential can be: Stimulatory Inhibitory Are both Or none at allAction potentials propagate in one direction because of: O K+ Voltage-gated Channels become inactive for a while O Nat Voltage-gated Channels become inactive for a while O K+ nongated Channels become inactive for a while O Nat nongated Channels become inactive for a whileYou generate action potentials in a neuron bathed in solution in a petri dish by applying a threshold-level depolarizing stimulus near its axon hillock. If the solution surrounding the neuron contained 5mM K+, 150 mM Na+, and 0 mM Ca2+ which of the following would you expect? The neuron would not be able to propagate action potentials down the entire length of the axon The neuron would not release neurotransmitter from the axon terminal The neurons action potentials would have an unusually long duration The neuron would have a resting membrane potential of zero
- Based upon the changes in permeability seen in the trace below and your knowledge of ion distributions across a cell, predict how ion movements would change during an action potential. Drag and drop each phrase into the appropriate box on the action potential trace. Drag the appropriate labels to their respective targets. Note: not all labels will be used. ►View Available Hint(s) Sodium (Na+) ions move to the axon Sodium (Na) ions move out of the axon Less potassium (K) ions move out of the axon Potassium (K) ions move out of the axon Potassium (K¹) ions move into the axon Sodium (Na) ions stop moving in Membrane potential (mv) +30 +10 0 -10- -30 -50 -70 -90 A PNa 0 PNa 5 6 1 PK Threshold PK 2 Reset HelpIn the figure to the left, name the 4 phases of the action potential (Note: you have to write in where phase 4 occurs). Describe what happens in each phase with a focus on Na+ and K+ flow through channels and the membrane potential. Discuss the importance of threshold. How does this relate to the concept of APs being all or none?Assume the membrane is only permeable to Na+ and K+, the electrical model of axon membrane is the following: Outside A INa gna ENa Ex D Inside The membrane potential at rest and at peak is -70mV and 45mV respectively; the potential of Sodium ion is 60mV and the potential of Potassium ion is -80mV. Find the ratio 9Na at rest and at peak. gK
