A case–control study of patients on antihypertensive drugs related an increased risk of myocardial infarction (MI) for patients using calcium channel blockers (Psaty, et al.,1995). In this study, cases were antihypertensive drug patients who had suffered a first fatal or nonfatal MI through 1993, and controls were antihypertensive patients, matched by demographic factors, who had not suffered a MI. Among the comparisons reported were patients receiving calcium channel (CC) blockers (with and without diuretics) and patients receiving β–blockers (with and without diuretics). Results of numbers of patient by drug/MI status combination are given in Table 1. Compute the odds ratio of suffering MI (CC blockers relative to β–blockers), and the corresponding 95% CI. Does it appear that calcium channel blockers are associated with higher odds (and thus probability) of suffering MI than β –blockers? Table 1: Observed cell counts for antihypertensive drug/MI data Occurrence of Myocardial Infarction Occurrence of Myocardial Infarction Yes No Total Anti-hypertensive Drug CC blocker 80 230 310 Anti-hypertensive Drug β–blocker 85 395 480 Total 165 625 790
A case–control study of patients on antihypertensive drugs related an increased risk of myocardial infarction (MI) for patients using calcium channel blockers (Psaty, et al.,1995). In this study, cases were antihypertensive drug patients who had suffered a first fatal or nonfatal MI through 1993, and controls were antihypertensive patients, matched by demographic factors, who had not suffered a MI. Among the comparisons reported were patients receiving calcium channel (CC) blockers (with and without diuretics) and patients receiving β–blockers (with and without diuretics). Results of numbers of patient by drug/MI status combination are given in Table 1. Compute the odds ratio of suffering MI (CC blockers relative to β–blockers), and the corresponding 95% CI. Does it appear that calcium channel blockers are associated with higher odds (and thus
Table 1: Observed cell counts for antihypertensive drug/MI data
|
|
|
Occurrence of Myocardial Infarction |
Occurrence of Myocardial Infarction |
|
|
|
|
Yes |
No
|
Total |
|
Anti-hypertensive Drug |
CC blocker |
80 |
230 |
310 |
|
Anti-hypertensive Drug |
β–blocker |
85 |
395 |
480 |
|
|
Total |
165 |
625 |
790 |
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|
|
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