A 50ml aliquot of a 0.1 M solution of a neutral drug was extracted with 2 x 5 ml ethyl acetate. The drug concentration in the combined organic layers was found to be 0.36 M. Calculate the partition coefficient for this drug under these conditions.

Partition coefficients (Kow = organic solvent concentration/aqueous concentration, usually reported as log Kow) are important for determining how efficiently organic compounds can be extracted from aqueous solutions. For example, consider the two substances below. Which will be more soluble in water? Hexamethylbenzene (log Kow = 6.41) O Diethyl ether (log Kow = 0.83)

A 19.8474 gram vial is used to calculate ethe partition coefficient of benzoic acid in a 50/50 DCM/water mixture using 59.9 mg of benzoic acid. If the vial + benzoic acid from the DCM layer weighs 19.8819 grams, what is the partition coefficient (DCM/water)?

(4c) Consider a situation where phenol is partitioned between water and benzene with a partitioncoefficient of 1.35in favour of benzene. Suppose we have 2g of phenol dissolved in 250ml of water. How muchphenol will be extracted into 250ml of benzene with a single extractionand howmuch phenol is left in water?.